All functions

RAIDS-package RAIDS

RAIDS: Accurate Inference of Genetic Ancestry from Cancer Sequences

add1KG2SampleGDS()

Add the genotype information for the list of pruned SNVs into the Profile GDS file

addGeneBlockGDSRefAnnot()

Append information associated to blocks, as indexes, into the Population Reference SNV Annotation GDS file

addRef2GDS1KG()

Add the information about the unrelated patients to the Reference GDS file

addStudy1Kg()

Append information about the 1KG samples into the Profile GDS file

computeAncestryFromSyntheticFile()

Select the optimal K and D parameters using the synthetic data and infer the ancestry of a specific profile

computeKNNRefSample()

Run a k-nearest neighbors analysis on one specific profile

computeKNNRefSynthetic()

Run a k-nearest neighbors analysis on a subset of the synthetic dataset

computePCAMultiSynthetic()

Project synthetic profiles onto existing principal component axes generated using the reference 1KG profiles

computePCARefSample()

Project specified profile onto PCA axes generated using known reference profiles

computePoolSyntheticAncestryGr()

Run a PCA analysis and a K-nearest neighbors analysis on a small set of synthetic data using all 1KG profiles except the ones used to generate the synthetic profiles

computeSyntheticROC()

Calculate the AUROC of the inferences for specific values of D and K using the inferred ancestry results from the synthetic profiles.

createStudy2GDS1KG()

Create the Profile GDS file(s) for one or multiple specific profiles using the information from a RDS Sample description file and the 1KG GDS file

demoKnownSuperPop1KG

The known super population ancestry of the demo 1KG reference profiles.

demoPCA1KG

The PCA results of the demo 1KG reference dataset for demonstration purpose. Beware that the PCA has been run on a very small subset of the 1KG reference dataset and should not be used to call ancestry inference on a real profile.

demoPCASyntheticProfiles

The PCA result of demo synthetic profiles projected on the demo subset 1KG reference PCA.

demoPedigreeEx1

The pedigree information about a demo profile called 'ex1'.

estimateAllelicFraction()

Estimate the allelic fraction of the pruned SNVs for a specific profile

generateGDS1KG()

Generate the GDS file that will contain the information from Reference data set (reference data set)

generateMapSnvSel()

Generate the filter SNP information file in RDS format

generatePhase1KG2GDS()

Adding the phase information into the Reference GDS file

getRef1KGPop()

Extract the specified column from the 1KG GDS 'sample.ref' node for the reference profiles (real ancestry assignation)

groupChr1KGSNV()

Merge the genotyping files per chromosome into one file

identifyRelative()

Identify genetically unrelated patients in GDS Reference file

matKNNSynthetic

A small data.frame containing the inferred ancestry on the synthetic profiles.

pedSynthetic

A small data.frame containing the information related to synthetic profiles. The ancestry of the profiles used to generate the synthetic profiles must be present.

prepPed1KG()

Prepare the pedigree file using pedigree information from Reference

prepSynthetic()

Add information related to the synthetic profiles (study and synthetic reference profiles information) into a Profile GDS file

pruningSample()

Compute the list of pruned SNVs for a specific profile using the information from the Reference GDS file and a linkage disequilibrium analysis

runExomeAncestry()

Run most steps leading to the ancestry inference call on a specific exome profile

runRNAAncestry()

Run most steps leading to the ancestry inference call on a specific RNA profile

select1KGPop()

Random selection of a specific number of reference profiles in each subcontinental population present in the 1KG GDS file

snpPositionDemo

A small data.frame containing the SNV information.

snvListVCF()

Generate a VCF with the information from the SNPs that pass a cut-off threshold

splitSelectByPop()

Group samples per subcontinental population

syntheticGeno()

Generate synthetic profiles for each cancer profile and 1KG reference profile combination and add them to the Profile GDS file